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KMID : 1171820040190010050
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Journal of Environmental and Sanitary Engineering
2004 Volume.19 No. 1 p.50 ~ p.56
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Effects of acute dibuty1 phthalate administration on hepatic lipid peroxidation and gamma-glutamy1 transferase activity in mice
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Choi Dal-Woong
Kim Young-Hwan
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Abstract
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Dibutyl phthalate (DBP) is used extensively in the plastic industry and has been known as an endocrine disruptor. Present study was undertaken to examine whether DBP can induce oxidative stress in mice. In this study, oxidative stress was measured in terms of the modification of lipid peroxidation and gamma-glutamyl transferase (GGT) activity. The serum toxicity index, level of lipid peroxidation and triglyceride (TG), and activity of GGT were measured in male ICR mice after a single administration of DBP (5 g/kg, po). DBP did not alter serum alanine aminotransferase (AL T), aspartate aminotransferase (AST), creatinine, glucose and cholesterol level. However, the treatment with DBP was found to significantly increase the level of lipid peroxidation in liver and lung. The TG content and activity of GGT in the liver of DBP-exposed animals was also increased. These results indicate that DBP can induce mild oxidative stress in mice. The GGT activity is considered to be increased as one of the adaptive defense mechanisms to oxidative stress induced by DBP.
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KEYWORD
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dibuty1 phthalate, lipid peroxidation, gamma-glutamy1 transferase, oxidative stress
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